ISOKEM™

Advancing Precision Measurement of Biological Activity

Harnessing molecular metabolism through atomic-tagging technologies to enable precision measurement of biological flux activity across clinical diagnostics, translational research, and biotechnology as a new class of measurement.

DEVELOPMENT STATUS ISOKEM-X: Metabolism-Based Detection of Viable Bacterial Infection NIH SBIR PHASE I (R43) Multi-site, multi-institutional study
Application
1R43AI208440-01
Scientific Review Group
ZRG1 DCAI-W (13)
Assigned
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Priority Alignment
Division of Microbiology and Infectious Diseases (DMID)
Program Director / Principal Investigator
Peter Gaied, D.O.

DEVELOPMENT SUPPORT

Picarro, Inc.
Santa Clara, California
Cambridge Isotope Laboratories (CIL)
Tewksbury, Massachusetts
Michigan State University Stable Isotope Core Facility
East Lansing, Michigan
TransPharm Preclinical Solutions
Jackson, Michigan
NIAID / DMID - HIGH-PRIORITY AREA OF INTEREST

“Development of rapid, highly sensitive and specific clinical diagnostics that are easy to use, cost-effective, and can diagnose individuals infected with pathogens”

OUR TECHNOLOGIES

A single measurement principle
Three distinct applications

App. No. 19/755,655

ISOKEM-X

Ex vivo clinical diagnostics

Rapid detection of viable bacterial infection & susceptibility testing across a variety of patient-derived specimens.

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App. No. 19/270,779  |  PCT/US2026/036378

ITRACE

In vivo detection and monitoring
of bacterial infection

Noninvasive detection and monitoring of bacterial infection and treatment progress through breath-based measurement.

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App. No. 19/688,479

KEMFlux

Laboratory metabolic measurement

Continuous, direct, and non-destructive measurement of enzymatic activity and its response to experimental perturbations across drug screening, cancer metabolism, metabolic disorders, microbiology, and bioprocessing.

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AMONG THE PATHOGENS TARGETED BY OUR TECHNOLOGY:

E. coliS. aureusK. pneumoniaeP. aeruginosaS. pneumoniae E. faecalisA. baumanniiSalmonella spp.Streptococcus spp.C. perfringens